What are the initial and terminal clinical signs of Borna disease as described?

What are the initial and terminal clinical signs of Borna disease as described?

• A. Initial CNS dysfunction - aggression
• B. Initial - colic, coughing, icterus; progresses to CNS dysfunction - aggression
• C. Initial fever with systemic signs
• D. Initial skin lesions with pruritus

Answer: (B)

Borna disease often shifts from non-neurologic, systemic signs to CNS involvement as it progresses. The initial presentation can include signs such as colic-like abdominal pain, respiratory signs like coughing, and icterus, reflecting systemic or hepatic involvement. As the virus affects the brain, neurological dysfunction emerges, frequently with behavioral changes such as aggression. This sequence fits the described pattern best, distinguishing it from conditions that start with CNS signs or with skin or fever-dominant presentations.

Borna disease often shifts from non-neurologic, systemic signs to CNS involvement as it progresses. The initial presentation can include signs such as colic-like abdominal pain, respiratory signs like coughing, and icterus, reflecting systemic or hepatic involvement. As the virus affects the brain, neurological dysfunction emerges, frequently with behavioral changes such as aggression. This sequence fits the described pattern best, distinguishing it from conditions that start with CNS signs or with skin or fever-dominant presentations.